Heteroresistance to Piperacillin-Tazobactam in Clinical Isolates of Escherichia coli Sequence Type 131

Household Clustering of Escherichia coli Sequence Type 131 Clinical and Fecal Isolates According to Whole Genome Sequence Analysis

Background.  Within-household sharing of strains from the resistance-associated H30R1 and H30Rx subclones of Escherichia coli sequence type 131 (ST131) has been inferred based on conventional typing data, but it has been assessed minimally using whole genome sequence (WGS) analysis. Methods.  Thirty-three clinical and fecal isolates of ST131-H30R1 and ST131-H30Rx, from 20 humans and pets in 6 h...

Clinical and Molecular Epidemiology of Escherichia coli Sequence Type 131 ( ST 131 ) 1 among Hospitalized Patients

Clinical and Molecular Epidemiology of Escherichia coli Sequence Type 131 (ST131) 1 among Hospitalized Patients Colonized Intestinally with Fluoroquinolone-Resistant E. coli 2 3 Jennifer H. Han, MD, MSCE#; Brian Johnston, BS; Irving Nachamkin, DrPH, MPH; Pam 4 Tolomeo, MPH; Warren B. Bilker, PhD; Xiangqun Mao, PhD; Connie Clabots, MT; 5 Ebbing Lautenbach, MD, MPH, MSCE*; and James R. Johnson, M...

Emergence of Escherichia coli sequence type 131 isolates producing KPC-2 carbapenemase in China.

Twenty-two KPC-2-producing Escherichia coli isolates were obtained from three hospitals in Hangzhou, China, from 2007 to 2011. One isolate, with OmpC porin deficiency, exhibited high-level carbapenem resistance. Pulsed-field gel electrophoresis showed that few isolates were indistinguishable or closely related. Multilocus sequence typing indicated that sequence type 131 (ST131) was the predomin...

Draft Genome Sequences of Two IMP-4-Producing Escherichia coli Sequence Type 131 Isolates in Australia

We report the draft genome sequences of two unrelated cases of Escherichia coli sequence type 131 (ST131) possessing the carbapenemase gene blaIMP-4. The E. coli ST131 SN5 isolate also possessed blaSHV-12 and plasmid-mediated quinolone-resistance genes. Wider dissemination of blaIMP-4 may occur due to the blaIMP-4-carrying L/M or HI2 plasmids among E. coli ST131 isolates.

Activity of Ceftolozane-Tazobactam (C/T) against Escherichia coli Isolates from U.S. Veterans in Relation to Co-resistance and Sequence Type 131 (ST131) H30/H30Rx Status